Immunomodulatory and antimicrobial activities of methanol extract of Uvaria chamae leaves in rats

The immunomodulatory and antimicrobial effects of methanol extract air-dried, powdered leaves Uvaria chamae (MEUL) was evaluated in this study using standard methods. Graded doses (50 mg/kg body weight, 100 200 weight 400 weight) the were administered to winster rats. control group given dimethyl sulphoxide (DMSO). Immunomodulatory effect assessed by delayed type hypersensitivity (DTH) haemagglutination. Antimicrobial activity against some clinical bacteria isolates also conducted. phytochemicals, alkaloids, flavonoids, glycosides, saponins, tannins, carbohydrates, steroids terpenoids detected. showed dose related increase cellular as assesed inflammed foot pad experimental animals with mean diameter ranging from 2.60±0.95 4.90±1.04 mm which 1.30±0.14 mm, (p<0.05). There significant haemagglutinating antibody titre sheep red blood cells ranged 272±21.27 1344±160.64 80±10.63 (p<0.01). leaf inhibitory test isolates. This work indicated that has potential immunostimulatory activity.